Epidemiology of non-transfusion dependent thalassaemias: an emerging global concern

Iron overload across the spectrum of non‐transfusion‐dependent thalassaemias: role of erythropoiesis, splenectomy and transfusions

Non-transfusion-dependent thalassaemias (NTDT) encompass a spectrum of anaemias rarely requiring blood transfusions. Increased iron absorption, driven by hepcidin suppression secondary to erythron expansion, initially causes intrahepatic iron overload. We examined iron metabolism biomarkers in 166 NTDT patients with β thalassaemia intermedia (n = 95), haemoglobin (Hb) E/β thalassaemia (n = 49) ...

Cryptococcosis: An Emerging Airborne Mycosis of Global Concern

Cryptococcosis, an emerging highly infectious respiratory mycosis, is mainly caused by Cryptococcus neoformans and Cryptococcus gattii, which exist as saprobe in the environment. Currently, nine molecular types, five in C.neoformans and four in C. gattii are identified. The disease occurs in sporadic and epidemic form resulting into significant morbidity and mortality, especially in immunocompr...

Perfluorinated Chemicals: an emerging concern

Non-transfusion-dependent thalassemias.

Non-transfusion-dependent thalassemias include a variety of phenotypes that, unlike patients with beta (β)-thalassemia major, do not require regular transfusion therapy for survival. The most commonly investigated forms are β-thalassemia intermedia, hemoglobin E/β-thalassemia, and α-thalassemia intermedia (hemoglobin H disease). However, transfusion-independence in such patients is not without ...

Microplastic--an emerging contaminant of potential concern?

Larn ed D ico u res Intent. The intent of Learned Discourses is to provide a forum for open discussion. These articles reflect the professional opinions of the authors regarding scientific issues. They do not represent SETAC positions or policies. And, although they are subject to editorial review for clarity, consistency, and brevity, these articles are not peer reviewed. The Learned Discourse...